Crystal Engineering of Organic Cocrystals by the Solid ...

2005-3-7 · The solid-state grinding approach to preparing cocrystals is an alternative to the traditional method of solution crystallisation, and possesses several distinct advantages. This review first demonstrates that the approach of solid-state cocrystal preparation is well established in the literature by providing a brief historical account of its ...

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Pharmaceutical Solid-state Forms

2020-4-21 · salts, and cocrystals (Figure 1). It should be noted that there are two commonly accepted pharmaceutical definitions of polymorph. The Food and Drug Administration (FDA) definition of a polymorph includes hydrates, solvates, and amorphous materials [1]. The purist definition, from solid-state pharmaceutics, defines a polymorph as forms with the

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A New Method for Classification of Salts and Cocrystals ...

From these results, differences between a salt and a cocrystal were observed in their solid-state UV/Vis absorption spectra for indomethacin complexes. Therefore, it is suggested that solid-state UV/Vis absorption spectra can be used as a new technique to classify salts and cocrystals. PMID: 31474734 [Indexed for MEDLINE] MeSH terms. Arginine ...

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Solid-state characterization and solubility enhancement of ...

Solid-state characterization and solubility enhancement of apremilast drug–drug cocrystals ... Three isostructural cocrystals of apremilast, a novel anti-psoriasis oral …

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Understanding the solution phase chemistry and solid …

Cocrystals have drawn a lot of research interest in the last decade due to their potential to favorably alter the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients. This dissertation focuses on the thermodynamic stability and solubility of pharmaceutical cocrystals. Specifically, the objectives are to; (i) investigate the influence of coformer properties ...

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Pharmaceutical Cocrystals: New Solid Phase Modification ...

2018-1-25 · Another generally accepted definition of pharmaceutical cocrystals, which was coined in the context of the Indo-US Bilateral Meeting on the Evolving Role of Solid State Chemistry in Pharmaceutical Science (India, February 2012), is the following: "Cocrystals are solids that are crystalline single phase materials composed of two or more ...

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Interrelation of the dissolution behavior and solid-state ...

2017-1-1 · The series of cocrystals examined herein exhibits an inverse correlation between the intrinsic dissolution rates and the melting/decomposition temperatures as well as the dimension of the hydrogen-bonded ACZ aggregates found in the corresponding crystal structure, indicating that solid-state stability is the major influence on dissolution ...

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Characterization of Pharmaceutical Cocrystals and Salts …

2020-10-13 · Characterization of Pharmaceutical Cocrystals and ... Solid-State NMR Spectroscopy Li Zhao Iowa State University and Ames Laboratory Michael P. Hanrahan ...

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New method for cocrystallization in the solid state ...

Synthesis and structural characterization of cocrystals of ...

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A Review on Pharmaceutical Cocrystals

2018-7-16 · Cocrystals can be produced using solid-state synthesis green technologies high yield, no solvent or by-products. CONCLUSION. Thus cocrystal performs a major role in pharmaceuticals. By enhancing solubility they prevent the excess use of solvents. Also, the bioperformance and bioavailability can be enhanced.

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Solid State Characterization and Tableting Studies of ...

2018-1-19 · The prepared cocrystals were evaluate for, solid state characterization by FTIR, PXRD, Raman spectroscopy and evaluated for tableting performance. Results: The formation of cocrystals has been confirmed by FTIR and Raman spectroscopy. The …

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Pharmaceutical Cocrystals and Co-amorphous systems ...

2019-12-9 · Solid dispersions: As shown in figure 1, co-amorphous formulations are a class of glass solutions which itself is a subcategory of solid dispersions. Dispersion of one or more active ingredients in an inert carrier at the solid state prepared by the melting, solvent, or melting-solvent method is the common definition of solid dispersions.

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Solid State Photoreactions of Organic Cocrystals and Alloys

2008-4-24 · of solid state properties by incorporating additional components within a single crystal is emerging as a major field of research. 12 These multicomponent solids can be designed as cocrystals or solid solutions (See Figure 3). molecular crystal cocrystal solid solution Figure 3. …

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deepblue.lib.umich

2021-8-3 · UNDERSTANDING THE SOLUTION PHASE CHEMISTRY AND SOLID STATE THERMODYNAMIC BEHAVIOR OF PHARMACEUTICAL COCRYSTALS . by . Chinmay Maheshwari . A dissertation submitted in the partial

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Solid emission color tuning of organic charge transfer ...

2019-2-5 · Solid emission color tuning of organic charge transfer cocrystals based on planar π-conjugated donors and TCNB Journal of Solid State Chemistry ( IF 3.498) Pub Date : 2019-02-04, DOI: 10.1016/j.jssc.2019.02.005

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Wiley Solid State Development and Processing of ...

Solid State Development and Processing of Pharmaceutical Molecules: Salts, Cocrystals, and Polymorphism Michael Gruss (Editor), Raimund Mannhold (Series Editor), Helmut Buschmann (Series Editor), Jörg Holenz (Series Editor) E-Book 978-3-527-82306-2 September 2021 $148.99

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Pharmaceutical Cocrystals: An Overview

The generally accepted definition of cocrystals was proposed by 46 scientists during the Indo-US Bilateral Meeting sponsored by the Indo-US Science and Technology Forum titled "The Evolving Role of Solid State Chemistry in Pharmaceutical Science", which was organized in Delhi, India in 2012.

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Revealing Solid Properties of High-energy-density ...

2019-2-4 · Solid-state properties of the cocrystals: thermodynamics, structure, explosion and safety. The cooperation of the hydrogen bonding and the molecular polarizabilities increases the binding energies ...

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Discovery of New Proxyphylline-Based Chiral Cocrystals ...

2020-6-3 · A cocrystal screening of the chiral drug "proxyphylline" (PXL) and achiral coformers was performed using dry or solvent assisted grinding and evaporation methods, yielding 10 different original solid forms with a 1:1 stoichiometry. Among them, three anhydrous cocrystals and a monohydrated conglomerate forming system have been identified with salicylic acid (SA). The crystal structures of ...

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Pharmaceutical Cocrystals

2017-6-30 · The cocrystals of carbamazepine‐nicotinamide (CBZ‐NCT) and carbamazepine‐saccharin (CBZ‐SAC) have displayed polymorphism. Solid State Properties of …

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Cocrystals

Cocrystals offer great potential: Improvement of solid state properties: several important characteristics of pharmaceutical substances like solubility, bioavailability, stability, hygroscopicity, morphology, filtration and flowability can be modified by means of …

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Solid state manipulation of lornoxicam for cocrystals ...

The lornoxicam cocrystals were obtained with improved physicochemical characteristics. Solid state manipulation of lornoxicam for cocrystals--physicochemical characterization Drug Dev Ind Pharm. 2014 Sep;40(9):1163-72. doi: 10.3109/03639045.2013.804834. Epub 2013 Jul 5. Authors ...

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Pharmaceutical Cocrystals: New Solid Phase Modification ...

Another generally accepted definition of pharmaceutical cocrystals, which was coined in the context of the Indo-US Bilateral Meeting on the Evolving Role of Solid State …

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Pharmaceutical Cocrystals: New Solid Phase Modification ...

Another generally accepted definition of pharmaceutical cocrystals, which was coined in the context of the Indo-US Bilateral Meeting on the Evolving Role of Solid State Chemistry in Pharmaceutical Science (India, February 2012), is the following: "Cocrystals are …

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Solid-State Quantification of Cocrystals in Pharmaceutical ...

2021-3-12 · To enable the continuous production of cocrystal-containing pharmaceutical tablets, guaranteeing the cocrystal content of the final pharmaceutical tablets in the solid state is critical. This study demonstrates the quantification of caffeine-glutaric acid cocrystals in model tablets using transmission low-frequency Raman spectroscopy. Although distinguishing between cocrystals and raw ...

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Synthesis and structural characterization of cocrystals of ...

2020-11-5 · Solid-state NMR is frequently used to characterize cocrystals, particularly when they have been produced by mechanical grinding and so single-crystal diffraction is not possible [,, ]. NMR chemical shifts are sensitive to local chemical environments, and so, for example, can distinguish between cases where a hydrogen has been transferred ...

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New method for cocrystallization in the solid state ...

2021-8-2 · Pharmaceutical cocrystals have been effectively prepared through the solid-state co-grinding method. It is a combination of one or more cocrystal formers and an active pharmaceutical ingredient formed through the interaction of the molecules. …

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apremilast drug-drug cocrystals Solid-state ...

2018-8-9 · S1 Electronic Supplementary Information Solid-state characterization and solubility enhancement of apremilast drug-drug cocrystals Feng-Yuan Wang ab, Qi Zhang a, Zaiyong Zhang a, Xiaoyi Gong a, Jian-Rong Wang a, and Xuefeng Mei *a a Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, …

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o Solid State Characterization and Tableting Studies of ...

2018-12-21 · cocrystals were prepared by solution cocrystallization technique by using ethanol as a solvent and nicotinamide as a coformer in the ratio of 1:1 & 1:2. The prepared cocrystals were evaluate for, solid state characterization by FTIR, PXRD, Raman spectroscopy and evaluated for tableting performance. Results: The formation of cocrystals has been

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Prediction of Solid State Properties of Cocrystals Using ...

The data set includes 14 caffeine cocrystals, 9 theophylline cocrystals, 9 nicotinamide cocrystals, and 29 isonicotinamide cocrystals. Model-I is trained using known cocrystal melting temperatures, lattice energies, and crystal densities, to predict all three solid-state properties simultaneously.

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Solid State Synthesis and Hierarchical Supramolecular Self ...

2007-10-13 · Abstract This paper describes the solid-state synthesis and systematic studies of versatile supramolecular self-assembly of 14 new series of organic salt cocrystals. Hierarchical self-assembly in the solid state utilizes the cooperative interaction of hydrogen bonding, electrostatic and π–π interactions. These salts are crystallized as a highly ordered self-assembly directed by ...

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Understanding solid-state processing of pharmaceutical ...

2021-5-15 · Milling and co-milling of pharmaceutical cocrystals can often result in solid-state phase transformations and dissociation into its individual components. Therefore, this study attempts to create an understanding of cocrystal API solid state processing with a …

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